Ageing's Effects on Cellular Function

As people age, the ability of their cells to function begins to decline, leading to a range of health issues collectively termed cellular dysfunction. This loss of cellular functionality can affect various cellular mechanisms, including DNA repair, protein homeostasis, and cellular communication, ultimately impacting the overall health and well-being of people as they grow older. Understanding cellular dysfunction is crucial for developing strategies to promote healthy aging and mitigate age-related diseases.

Understanding Cellular Dysfunction

Cellular dysfunction refers to the failure of cells to maintain their normal functions due to accumulated damage and altered regulatory processes. Several key factors contribute to cellular dysfunction in aging:

1. DNA Damage and Repair: Over time, DNA accumulates damage from environmental factors like UV radiation and oxidative stress. The efficiency of DNA repair mechanisms declines with age, leading to genetic mutations and genomic instability, which can contribute to cancer and other age-related diseases.